The Effect of Tamoxifen on the Neonatal Development of Rat Penis
نویسندگان
چکیده
375 Abstract: In rats penis development a seen two stages in prenatal life, the second stage is androgen hormone dependent chondrocyte and osteocyte differentiation period. To investigate Tamoxifane (Tx) administration on the developmental anomalies of penis. The newborn male rats were injected with 100 μg Tamoxifen subcutaneously from the day of birth to fifth day. This changes in Os penis and glans penis were investigated after the rats had been sacrificed and their penis were removed on the days 14.0, 21.0, 28.0, 35.0 and 60.0 Having been fixed in neutral formaline of 10%, the totally taken penis werembedded into paraffin blocks. The obtained paraffin sections were stained with Hematoxylene Eosin, Verhoeff and Tripple. The structural changes in development of Os penis and glans penis were investigated.
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